Hank and Evan head for Florida when Eddie's parole hearing is scheduled but Eddie's new ex-con friend raises concerns. Boris takes Hank out of the U.S. to team up with a doctor to research gene therapy. Elsewhere, the doctor who's filling in for Hank irks Divya. Anastasia Griffith guest stars.

After Hank, a young doctor on the fast track to success, falls from grace when he is blamed for the death of a hospital trustee, he inadvertently stumbles into the world of private medical service for the elite denizens of the Hamptons. With the encouragement of his younger brother and an ambitious young woman who volunteers to be his physician's assistant, Hank reluctantly agrees to be a "Concierge Doctor" for the summer.

On the day that Hank had previously planned to get married he spends time with Jill. Meanwhile, a Tuberculosis scare at a high-end Italian restaurant leads to a mysterious illness for the head chef, and Evan and Divya learn to work together. Hank and Divya are called in to one of the Hamptons’ hottest restaurants to give TB tests to the entire staff, per the new requirement by the health inspector. But the hard-working owner and head chef, Allison Moore, who has been burning it on both ends

Royal Pains centers on a young E.R. doctor who, after being wrongly blamed for a patient's death, moves to the Hamptons and becomes the reluctant "doctor for hire" to the rich and famous. When the attractive administrator of the local hospital asks him to treat the town's less fortunate, he finds himself walking the line between doing well for himself and doing good for others.